Publications by authors named "M Bucovsky"
Pregnancy and lactation-associated osteoporosis (PLO) is a rare presentation of early-onset osteoporosis characterized by low trauma and spontaneous fractures during late pregnancy/lactation. Herein, we report areal BMD (aBMD) by DXA and volumetric BMD (vBMD), microarchitecture, and strength at the distal radius and tibia by HR-pQCT in 59 women with PLO-in comparison to both healthy premenopausal controls (n = 28) and premenopausal women with idiopathic osteoporotic fractures not associated with pregnancy/lactation (non-PLO IOP; n = 50). Women with PLO (aged 34 ± 6 yr) had a more severe clinical presentation than non-PLO IOP: 80% had vertebral and 92% had multiple fractures (p<.
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- A study compared bone health in elderly women with a history of patella fractures to those without fractures and those with forearm fractures, using advanced imaging techniques.
- Women with patella fractures showed 6.5% lower bone mineral density at the hip compared to those without fractures, while forearm fracture patients had lower bone density and structural quality throughout multiple sites.
- The findings indicate that patella fractures may be linked to skeletal fragility similar to more recognized osteoporotic fractures like forearm fractures, suggesting the need for further evaluation of their implications on bone health.
The basis for increased fracture risk in type 2 diabetes (T2DM) is not well understood. In this multi-ethnic, population-based study (n = 565), we investigated bone microstructure, trabecular plate/rod morphology, and mineralization in women with T2DM (n = 175) with and without fracture using a second-generation HRpQCT and individual trabecula segmentation and mineralization (ITS; ITM). Covariate-adjusted aBMD was 3.
View Article and Find Full Text PDFContext: We previously reported that sequential teriparatide followed by denosumab substantially increases BMD in premenopausal idiopathic osteoporosis (PremenIOP).
Objective: To determine whether administration of bisphosphonates after denosumab cessation is associated with stable BMD in PremenIOP.
Design: Open-label extension study.
Changes in Bone Quality after Treatment with Etelcalcetide.
Clin J Am Soc Nephrol
November 2023
Article Synopsis
- - The study investigates the effects of etelcalcetide, a treatment for secondary hyperparathyroidism in dialysis patients, on bone health, specifically aiming to improve bone quality and strength without harming bone tissue.
- - Conducted over 36 weeks with 22 participants, the results showed significant reductions in parathyroid hormone levels and increases in bone mineral density and trabecular quality, suggesting positive impacts on bone health.
- - However, bone biopsies indicated a decrease in bone formation rate, highlighting a complex interaction between treatment and bone remodeling processes.