Phosphatidylinositol 4,5-bisphosphate drives the formation of EGFR and EphA2 complexes.

Receptor tyrosine kinases (RTKs) regulate many cellular functions and are important targets in pharmaceutical development, particularly in cancer treatment. EGFR and EphA2 are two key RTKs that are associated with oncogenic phenotypes. Several studies have reported functional interplay between these receptors, but the mechanism of interaction is still unresolved.

Psychological flexibility as a mediator in the relationship between resilience and academic burnout among Doctor of Physical Therapy students: A structural equation modeling study.

Background And Aims: Although resilience has been identified as an important factor for mitigating burnout among health profession students, little is known regarding the modifiable factors that should be emphasized to improve resilience in this population. The purpose of this study was to evaluate psychological flexibility as a modifiable mediator of the relationship between resilience and academic burnout among healthcare students.

Methods: This cross-sectional study was conducted with 369 Doctor of Physical Therapy (DPT) students from universities across the United States.

Atomically dispersed nickel in CeO aerogel catalysts completely suppresses methanation in the water-gas shift reaction.

Nickel-based catalysts are widely studied for water-gas shift (WGS), a key intermediate step in hydrogen production from carbon-based feedstocks. Their viability under practical conditions is limited at high temperatures when Ni aggregates and converts CO to methane, an undesirable side product. Because experimental and computational studies identify undercoordinated Ni step sites as most active toward CH formation, we eliminate Ni step sites by atomically dispersing Ni into networked, nanoparticulate CeO aerogels.

Novel candidate taxa contribute to key metabolic processes in Fennoscandian Shield deep groundwaters.

The continental deep biosphere contains a vast reservoir of microorganisms, although a large proportion of its diversity remains both uncultured and undescribed. In this study, the metabolic potential (metagenomes) and activity (metatranscriptomes) of the microbial communities in Fennoscandian Shield deep subsurface groundwaters were characterized with a focus on novel taxa. DNA sequencing generated 1270 de-replicated metagenome-assembled genomes and single-amplified genomes, containing 7 novel classes, 34 orders, and 72 families.