Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats.

In infants, a common consequence of systemic perinatal insults is disruption of neonatal brain development. Such insults can cause cerebral palsy, cognitive delay, epilepsy and other chronic neurologic deficits in children. The mechanisms underlying disruption of brain development after perinatal insults are poorly defined.

Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience.

Background: Fluridil, a novel topical antiandrogen, suppresses the human androgen receptor. While highly hydrophobic and hydrolytically degradable, it is systemically nonresorbable. In animals, fluridil demonstrated high local and general tolerance.

[Clinical characteristics of mycosis fungoides and Sézary syndrome].

Mycosis fungoides and Sézary syndrome are typical representatives of malignant lymphomas of the T-series affecting the skin. Both affections have a varied clinical picture, a different spectrum of histological and laboratory findings and lack a uniform prognosis. In the submitted review the authors discuss in more detail all mentioned aspects of the disease and draw attention to new therapeutic possibilities.

Morphology of epithelizing varicose ulcers following He-Ne laser therapy.

The present study is a report on the morphological, particularly ultrastructural findings in the newly formed epidermis of varicose ulcerations after a series of irradiations with a low energy He-Ne laser. The ultrastructural alterations are interpreted as most probably conditioned by the biostimulating effect of the radiation and they are compared with the results obtained by other investigators studying these problems and with findings in the epithelium of embryonal epidermis as well as in the epidermis exposed to ultraviolet radiation.