Publications by authors named "M Brzoska"
Since even low-level environmental exposure to cadmium (Cd) can lead to numerous unfavourable health outcomes, including damage to the nervous system, it is important to recognize the risk of health damage by this xenobiotic, the mechanisms of its toxic influence, and to find an effective protective strategy. This study aimed to evaluate, in a female Wistar rat model of current human environmental exposure to Cd (1 and 5 mg/kg of diet for 3-24 months), if the low-to-moderate treatment with this element can harm the brain and whether the supplementation with a 0.1% L.
View Article and Find Full Text PDFDialysis access thrombosis is a common complication in the process of care. With the introduction of endovascular AV-fistulas [AVF]s the situation gained complexity with new potential thrombosis localizations. Several thrombectomy methods are available for recanalization of thrombosed AVFs ranging from invasive surgical methods to minimal invasive endovascular approaches.
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- Cadmium exposure can negatively impact human health, particularly the nervous system, as it acts as a prooxidant that creates oxidative stress.
- Research involving female rats showed that long-term exposure to cadmium at low to moderate levels leads to oxidative stress-related damage in the brain.
- Supplementation with chokeberry extract significantly alleviated the harmful effects of cadmium, suggesting it may serve as an effective protective agent against oxidative injury.
The impact of cadmium (Cd) on the function and structure of the kidney and the potential protective effect of an extract from L. berries were investigated in a rat model of low- and moderate-level environmental exposure to this heavy metal (1 and 5 mg Cd/kg feed for up to 24 months). The sensitive biomarkers of Cd-induced damage to the kidney tubules (N-acetyl-β-D-glucosaminidase (NAG), alkaline phosphatase (ALP), β2-microglobulin (β2-MG), and kidney injury molecule-1 (KIM-1) in the urine), clinically relevant early markers of glomerular damage (albumin in the urine and creatinine clearance), and other markers of the general functional status of this organ (urea, uric acid, and total protein in the serum and/or urine) and Cd concentration in the urine, were evaluated.
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- * It reviews research showing that even low levels of Cd found in industrialized countries can lead to kidney damage and chronic kidney disease (CKD).
- * The study identifies specific concentration thresholds in blood and urine that indicate potential harm, suggesting that current environmental exposure levels pose a risk to kidney health.