Publications by authors named "M Brunat-Mentigny"
Article Synopsis
- A phase II trial (OSAD93) tested the effectiveness of combining ifosfamide (IFO) and cisplatin (CDDP) without doxorubicin as a neoadjuvant treatment for adult osteosarcoma, focusing on patients with localized high-grade tumors.
- The study included 60 patients who received four courses of chemotherapy, with the primary goal being a Good Histological Response (GHR) of 10% or fewer residual tumor cells in over 30% of patients, and secondary outcomes of disease-free survival (DFS), overall survival (OS), and toxicity.
- Although the GHR target was not achieved, the study showed promising long-term survival rates (5-year DFS 51.
The presence of multifocal or diffuse nephrogenic rests (NRs) in one or both kidneys is termed nephroblastomatosis (Nbm). Nbm may be a predisposing factor for Wilms' tumour (WT). The aim of this retrospective study was to evaluate the impact of Nbm on the outcome of WT in children.
View Article and Find Full Text PDFUnlabelled: This study evaluates histological response, long-term outcome, and toxicity in an intensive chemotherapy program given before surgery.
Patients And Methods: Sixty-two patients (39 males, 23 females: median age 14) with biopsy, chest computerised-tomography, technetium bone-scan and magnetic resonance imaging, were enrolled. Primary localisations were femur (44%) and tibia (26%).
Purpose: We analyzed the clinical features and outcome of patients with radiation-associated osteosarcoma treated during the era of contemporary chemotherapy.
Patients And Methods: The characteristics and outcome of 23 patients (17 males and six females) treated during childhood or adolescence for a solid tumor who later developed osteosarcomas within the radiation field between 1981 and 1996 were reviewed.
Results: The median dose of radiation delivered to the first cancer was 47 Gy.