Publications by authors named "M Brini"
Objective: The aim of this study was to assess the color stability of two microhybrid composite resins after immersion in different coloring solutions for 4 weeks.
Materials And Methods: Sixty disc-shaped samples (2 mm in thickness and 10 mm in diameter) were prepared according to ISO standard 4049. Two composite resins were used: Filtek Z350 XT (3M ESPE) and Harvard Restore (Harvard Dental International GmbH).
Article Synopsis
- - The study investigates how calcium (Ca) transfer between the endoplasmic reticulum (ER) and mitochondria, crucial for energy production, is affected by the distance between these organelles, particularly in the context of Parkinson's disease (PD).
- - Researchers found that a specific distance of approximately 20 nm between ER and mitochondria enhances Ca transfer and supports optimal mitochondrial function, highlighting the importance of maintaining this distance.
- - In astrocytes derived from PD patients, the natural distance for efficient Ca transfer was reduced, leading to decreased mitochondrial function, but restoring the 20 nm distance improved Ca uptake, suggesting new ways to manage mitochondrial health.
Article Synopsis
- * ERO1A depletion in SEPN1 knockout cells enhances ER redox balance, improves mitochondrial function, and combats diaphragmatic weakness in mice, while ERO1A knockout shows beneficial effects on ER stress and MAM functionality.
- * ERO1A overexpression is observed in muscle biopsies from SEPN1-RM patients, and the ER stress inhibitor tauroursodeoxycholic acid (TUDCA) improves bio
Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?
Antioxidants (Basel)
February 2024
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each characterised by distinct clinical manifestations and underlying pathological mechanisms. While some cases have a genetic basis, many NDs occur sporadically. Despite their differences, these diseases commonly feature chronic neuroinflammation as a hallmark.
View Article and Find Full Text PDFMitochondrial and lysosomal activities are crucial to maintain cellular homeostasis: optimal coordination is achieved at their membrane contact sites where distinct protein machineries regulate organelle network dynamics, ions and metabolites exchange. Here we describe a genetically encoded SPLICS reporter for short- and long- juxtapositions between mitochondria and lysosomes. We report the existence of narrow and wide lysosome-mitochondria contacts differently modulated by mitophagy, autophagy and genetic manipulation of tethering factors.
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