Concealed by darkness: Combination of NMR and HRMS reveal the molecular nature of dissolved organic matter in fractured-rock groundwater and connected surface waters.

Detailed molecular composition of solid phase extracted dissolved organic matter (SPE) collected from fractured-rock groundwater was compared to connected surface river water at two different watersheds in the unconfined chalk aquifer of Champagne in France using full scan ultrahigh resolution electrospray and photoionization Fourier transform ion cyclotron mass spectrometry (FT-ICR MS), Orbitrap tandem MS (MS/MS) and H magnetic resonance spectroscopy (NMR). H NMR spectroscopy indicated that groundwater SPE carried a higher contribution of aliphatic compounds while surface river waters SPE were enriched in carboxyl-rich alicyclic molecules (CRAM), acetate derivatives and oxygenated units. Furthermore, we show here that use of photoionization (APPI(+)) in aquifer studies is key, ionizing about eight times more compounds than ESI in surface river water samples, specifically targeting the dissolved organic nitrogen pool, accounting for more than 50% of the total molecular space, as well as a non-polar, more aromatic fraction; with little overlap with compounds detected by ESI(-) FT-ICR MS.

Preserving bone in cancers of the elderly: A necessity.

The occurrence of bone fractures is frequent in the elderly population, and in cancer patients, especially with bone metastases. The growing incidence of cancer associated with an aging population implies important health challenges, including bone health. Decisions on cancer care in older adults have to take into account older adults' specificities.

Effects of Proton Pump Inhibitors Intake During Chemoradiotherapy for Rectal Cancer: a Retrospective Cohort Study.

Purpose: Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide and are involved in several drug interactions. Recently, several studies have suggested that PPIs may interfere with the efficacy of capecitabine. This study primarily aimed to investigate the effects of PPI intake on the pathologic response rate of patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy with capecitabine.

Proton Pump Inhibitors and Cancer: Current State of Play.

Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide and are overprescribed in patients with cancer; there is increasing evidence of their effects on cancer development and survival. The objective of this narrative review is to comprehensively identify cancer medications that have clinically meaningful drug-drug interactions (DDIs) with PPIs, including loss of efficacy or adverse effects, and to explore the association between PPIs and cancer. A PubMed search of English language studies published from 1 January 2016, to 1 June 2021 was conducted.

Complementary ESI and APPI high resolution mass spectrometry unravel the molecular complexity of a soil humeome.

High resolution mass spectrometry (HRMS) can resolve thousands of compounds in complex mixtures such as natural organic matter. However, HRMS is seldom sufficient to fully resolve the molecular heterogeneity of Humus in the soil matrix, especially if no preliminary simplification of Humus complexity is applied and if a single ionization technique is used. Here we show that HRMS, when applied with both photoionization (APPI) and electrospray ionization (ESI) and combined with the extensive molecular simplification provided by a humeomic fractionation, significantly increases identification of the molecular composition of soil Humus.