High-fidelity computational fluid dynamics modeling to simulate perfusion through a bone-mimicking scaffold.

Breast cancer cells sense shear stresses in response to interstitial fluid flow in bone and induce specific biological responses. Computational fluid dynamics models have been instrumental in estimating these shear stresses to relate the cell mechanoresponse to exact mechanical signals, better informing experiment design. Most computational models greatly simplify the experimental and cell mechanical environments for ease of computation, but these simplifications may overlook complex cell-substrate mechanical interactions that significantly change shear stresses experienced by cells.

A qualitative exploration of women's expectations of birth and knowledge of birth interventions following antenatal education.

Background: Expectations of birth, and whether they are met, influence postnatal psychological wellbeing. Intrapartum interventions, for example induction of labour, are increasing due to a changing pregnant population and evolving evidence, which may contribute to a mismatch between expectations and birth experience. NICE recommends antenatal education (ANE) to prepare women for labour and birth, but there is no mandated UK National Health Service (NHS) ANE curriculum.

Human Milk-Derived Fortifier to Reduce Hospital-Acquired Malnutrition in Uncomplicated Gastroschisis: A Case Report.

Gastroschisis is one of the most common congenital gastrointestinal disorders, occurring in about one in 1,953 infants born each year in the United States. Infants with gastroschisis rely on total parenteral nutrition (TPN) preoperatively, and due to intestinal function and dysmotility issues, continue to face feeding challenges postclosure, including feeding intolerance and increased risk of necrotizing enterocolitis (NEC). Postclosure, human milk-feeding is preferred over infant formula because of its associated reduced risk of feeding intolerance and NEC.

Primary healthcare's carbon footprint and sustainable strategies to mitigate its contribution: a scoping review.

Background: The escalating climate crisis poses a significant threat to global public health. The healthcare sector, designed to protect human health is a major contributor to greenhouse gas emissions, and thus, a key driver of climate degradation. This paradox endangers both planetary and human health, making the decarbonization of healthcare, including primary care, critical.