Publications by authors named "M Breuer"

Aspartate ammonia lyases catalyze the reversible amination of fumarate to l-aspartate. Recent studies demonstrate that the thermostable enzyme from sp. YM55-1 (AspB) can be engineered for the enantioselective production of substituted β-amino acids.

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Understanding how wildlife responds to the spread of human-dominated habitats is a major challenge in ecology. It is still poorly understood how urban areas affect wildlife space-use patterns and consistent intra-specific behavioural differences (i.e.

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As the survival prognosis of cancer patients continues to improve, the improvement in quality of life during and after cancer treatment is becoming increasingly important 1. Exercise therapy has a positive effect on so-called "patient-reported outcomes" 2. The combination of endurance training and individualized strength training plays a particularly important role here.

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In the search for alternative energy carriers that can replace conventional fossil fuels, sustainably produced oxygenated hydrocarbons represent a promising class of potential candidates. An illustrative member of this class of alternative biofuels are oxymethylene ethers (OMEs). This study makes a contribution to this objective by investigating hydroxy ethers, specifically methoxymethanol, ethoxymethanol, and 2-methoxyethanol.

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Article Synopsis
  • Phosphatidic acid phosphatase (PAP) is an important enzyme involved in lipid metabolism, converting phosphatidic acid into diacylglycerol, which is vital for synthesizing fats and cell membranes.
  • Researchers discovered that the antidepressant sertraline inhibits PAP activity in yeast and human cells, working through a noncompetitive mechanism and showing stronger inhibition than a common PAP inhibitor, propranolol.
  • Molecular docking studies indicate that sertraline interacts with non-catalytic parts of the enzyme, and tests in yeast demonstrate that overexpressing PAP can counteract the inhibitory effects of sertraline on yeast growth and lipid content.
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