Publications by authors named "M Bramble"
Article Synopsis
- The research focuses on the female reproductive system's diversity and function among tetrapods, highlighting challenges in comparing species due to unique adaptations.
- Using the brown anole (Anolis sagrei), the study analyzes gene expression across three regions of the reproductive tract through RNA-sequencing, identifying thousands of differentially expressed genes.
- The findings provide insights into shared and unique gene expression patterns, including a consistent Hox gene expression in mammals, and establish a foundation for future studies on reproductive organ function and evolution in tetrapods.
Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the world's poorest children and women of childbearing ages across regions of sub-Saharan Africa. Despite understanding the dietary factors that lead to konzo, the molecular markers and mechanisms that trigger this disease remain unknown. To identify potential protein biomarkers associated with a disease status, plasma was collected from two independent Congolese cohorts, a discovery cohort (n = 60) and validation cohort (n = 204), sampled 10 years apart and subjected to multiple high-throughput assays.
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- The CDCA7 protein, involved in ICF syndrome, has a unique carboxyl-terminal cysteine-rich domain (CRD) that binds to a specific DNA structure.
- This binding occurs preferentially with a hemi-methylated non-B DNA form, distinguishing CDCA7 from ICF mutants.
- CDCA7's concentration in specific chromatin regions during DNA replication suggests it plays a crucial role in directing DNA methylation at juxtacentromeric regions.
Introduction: Parkinson's disease (PD) is associated with a range of non-motor symptomologies such as anxiety and depression.
Objective: The purpose of this research was to investigate the prevalence and factors associated with mental health status in persons with PD.
Design: This retrospective data linkage study analysed a subset of data from the Sax Institute's 45 and Up Study based in the population of the state of New South Wales (NSW), Australia.
Introduction: This scoping review was undertaken to obtain conceptual clarification about how racism and cultural safety are understood by interdisciplinary health professionals globally in the aged care sector in regional, rural and remote areas. There is evidence in Australia and internationally that racism is a factor impacting significantly on the health of First Peoples and other racialised minorities. Recent policy changes in Australia have required health professionals to integrate cultural safety into their practice to mitigate racism and improve the health of older First Nations Australians and older people from diverse ethnic and cultural groups.
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