Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.

Macrophages have been linked to tumor initiation, progression, metastasis, and treatment resistance. However, the transcriptional regulation of macrophages driving the protumor function remains elusive. Here, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer.

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.

Background: Previous studies suggested that the metabolism is differently reprogrammed in the major subtypes of non-small cell lung cancer (NSCLC), squamous cell carcinomas (SCC) and adenocarcinomas (AdC). However, a comprehensive analysis of this differential metabolic reprogramming is lacking.

Methods: Publicly available gene expression data from human lung cancer samples and cell lines were analysed.

Single Versus Double Lung Retransplantation Does Not Affect Survival Based on Previous Transplant Type.

Background: Survival following retransplantation with a single lung is worse than after double lung transplant. We sought to characterize survival of patients who underwent lung retransplantation based on the type of their initial transplant, single or double.

Methods: The United Network for Organ Sharing database was queried for adult patients who underwent lung retransplantation from 2005 onward.

Normalization of Exhaled Carbonyl Compounds After Lung Cancer Resection.

Background: Quantitative analysis of specific exhaled carbonyl compounds (ECCs) has shown promise for the detection of lung cancer. The purpose of this study is to demonstrate the normalization of ECCs in patients after lung cancer resection.

Methods: Patients from a single center gave consent and were enrolled in the study from 2011 onward.