Publications by authors named "M Boules"
Background: Relapse after corticosteroid withdrawal in eosinophilic esophagitis is not well understood.
Objectives: Budesonide oral suspension (BOS) 2.0 mg twice daily (b.
Background: Prucalopride (1 or 2 mg once daily) is approved for treating adults with chronic idiopathic constipation (CIC).
Objectives: We determined the effect of age, body mass index (BMI), and renal function on the efficacy and safety of prucalopride in adults with CIC.
Design: Data were pooled from six 12-week, phase III-IV clinical studies in adults who received prucalopride (1 or 2 mg once daily) or placebo for CIC.
Article Synopsis
- The study investigates how previous esophageal dilation affects the effectiveness of swallowed corticosteroids in patients with eosinophilic esophagitis (EoE), particularly focusing on the responses to treatment.
- A post hoc analysis of a phase 3 study on budesonide oral suspension revealed that while histological responses were similar among patients regardless of dilation history, those with a history of dilation had lower dysphagia symptom response rates.
- The findings suggest that a history of esophageal dilation might complicate the relationship between histological results and dysphagia symptom or endoscopic efficacy outcomes in EoE treatment.
Background And Aims: Eosinophilic esophagitis (EoE) is associated with impaired health-related quality of life (HRQoL) and stigma perceptions. Therefore, we examined the real-world impact of EoE on the daily life and ability to function in adolescents (caregiver-reported) and adults with EoE in the United States of America in a noninterventional, cross-sectional, web-based survey.
Methods: HRQoL was assessed using the Short Form Health Survey (domains: vitality and social functioning) and the European Health Interview Survey (domain: sleep).
A Meta-Analysis Examining the Effect of Perioperative Biologic Disease-Modifying Anti-Rheumatic Medications on Postoperative Wound Complications in Various Orthopedic Surgeries.
J Clin Med
September 2024
This meta-analysis was designed to compare the risk of postoperative wound complications in various orthopedic surgeries (OSs) affected by the perioperative use of biologic disease-modifying anti-rheumatic drugs (bDMARDs). The odds ratio (OR) and mean difference (MD), with 95% confidence intervals (CIs), were calculated using dichotomous or continuous random or fixed-effect models, based on the meta-analysis data. This study incorporated 14 investigations conducted between 2005 and 2023, encompassing a total population of 19,021 individuals undergoing diverse OSs.
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