Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne.

The emergence of oral and topical retinoids was a major advance in the clinical management of acne vulgaris. However, the benefits of these agents were somewhat limited by the degree of side effects caused by these drugs. Over the last 15 years, researchers have sought compounds that can provide the manifold therapeutic benefits obtained with tretinoin and isotretinoin while minimizing the potential for irritation and other unwanted effects.

A preliminary clinical and histopathological study of laser skin resurfacing using a frequency-doubled Nd:YAG laser after application of Chromofilm.

Background And Objectives: Carbon dioxide (CO2) and Er:YAG lasers are commonly used for laser skin resurfacing. In demonstrating their efficacy, intra- and interoperator variability may be important. In attempting to solve this problem, a new concept was developed which combines a previous application of an exogenous chromophore onto the skin in a standardized way (Chromofilm) and irradiation with a millisecond, low-power pulsed laser.

A new method to improve penetration depth of dyes into the follicular duct: potential application for laser hair removal.

Background: Many persons seek to decrease hair growth and hair density. Although a variety of epilating methods are available, a practical and permanent hair removal treatment is needed.

Objective: The purpose of this study was to evaluate a new method of obtaining a better penetration depth of dyes into the follicular duct.

Laser skin resurfacing using a frequency doubled Nd:YAG laser after topical application of an exogenous chromophore.

Background And Objectives: Although laser skin resurfacing performed with CO(2) or Er:YAG lasers is efficient, side effects such as prolonged postoperative erythema, delayed healing, scarring, and pigmentation, have been reported. These side effects are due to skin characteristics but also to variations of the thermal effects associated with laser skin resurfacing. The study aimed to evaluate a new laser resurfacing method based on a previous topical application of an exogenous chromophore in order to have reproducible thermal effects.

A novel in vitro model for the study of human keratinocyte/leucocyte interactions under autologous conditions.

Keratinocyte/leucocyte interactions have become an area of intense investigations in the last decade. However, few convenient in vitro models are available at present. We have therefore designed a novel in vitro system for autologous human keratinocyte/leucocyte co-culture.