Morphological changes in the liver after the administration of piroxicam and its complexes with Bio-Ions Cu (II), Co (II), Zn (II) to the rats.

In this research we present the results of the liver histopathological examinations after the administration of the Piroxicam (Pirox) and its complex combinations with metal bio-ions Cu (II), Co (II), Zn (II) to rats (White Wistar, 150-180 gr.). The results of the histological investigations are presented separately for each compound revealing the modifications after 24 hours and after 7 days.

A comparative study regarding the morphological alteration on the gastric level after the administration of piroxicam and complexes with bio-ions Cu(II), Co(II), Zn(II) to rats.

The complex combinations of Piroxicam (Pirox) with the metallic bio-ions: Cu(II), Co(II), Zn(II) have been obtained and defined in a previous stage by physical-chemical methods (IR, X, SM, CSS-UV, DTA, DTG), an toxicological and biochemical aspect. In this research are presented the results of the histological examinations at the level of stomach, for each compound, at 24 hours and at 7 days after the administration of the Piroxicam and of its complexes to rats. The tissues histo-pathological investigation has pointed out lesions the glandular stomach level (necrosis, ulcers) especially after the administration of the Piroxicam and of the Zn-Pirox complex.

Neurobehavioral and biochemical response to manganese and selenium exposure in rats.

Aiming to extend previous findings, male Wistar rats were treated per os for 13 weeks with manganese chloride in two doses: 300 mg/kg body weight (group I) and 20 mg/kg b.w. (II), the former was associated (III) with a microdose (1 ppm) of natrium selenite.