Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report.

Background: Immunotherapy treatment for coronavirus disease 2019 combined with antiviral therapy and supportive care remains under intense investigation. However, the capacity to distinguish patients who would benefit from immunosuppressive or immune stimulatory therapies remains insufficient. Here, we present a patient with severe coronavirus disease 2019 with a defective immune response, treated successfully with interleukin-7 on compassionate basis with resultant improved adaptive immune function.

Effect of hemorrhage on medial collateral ligament healing in a mouse model.

Background: Medial collateral ligament injuries heal by a scar response.

Hypothesis: Increased hemorrhage at the site of medial collateral ligament injury improves healing.

Study Design: Controlled laboratory study.