Publications by authors named "M Borys"
This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon-γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their pharmacokinetics (PK), immunogenicity, potency, and overall clinical performance due to its influence on protein clearance via hepatic asialoglycoprotein receptors (ASGPR). The ASGPR recognizes and binds to glycoproteins exposed to terminal galactose or N-acetylgalactosamine residues, leading to receptor-mediated endocytosis. Recent studies have demonstrated that sialylation of O-linked glycan plays a role in protecting against macrophage galactose lectin (MGL)-mediated clearance.
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- - ICU patients are at high risk for vitamin D3 deficiencies due to factors like severe illness, treatments, malnutrition, and aging, especially during continuous renal replacement therapy (CRRT), which can remove vitamin D3 from the body.
- - The study will utilize a randomized controlled trial to compare the effects of two different doses of vitamin D3 (750,000 IU vs. 500,000 IU) on critically ill patients with severe deficiencies while undergoing CRRT across multiple hospitals in Poland.
- - The aim is to determine if a 50% increase in vitamin D3 supplementation is more effective in raising serum levels in these patients within a week, helping to address the issue of hypovitaminosis D in critically ill individuals. *
Article Synopsis
- * This study examined how well three types of CRRT filters (PS, PAN PEI, and PAN) adsorb linezolid in vitro, using bovine blood and saline solutions.
- * Results showed that the PAN PEI filter significantly adsorbed linezolid, reducing its concentration by 52% in saline and 27% in blood, while no significant adsorption was seen with PAN or PS filters.
Purpose: Developing innovative precision and personalized cancer therapeutics is essential to enhance cancer survivability, particularly for prevalent cancer types such as colorectal cancer. This study aims to demonstrate various approaches for discovering new targets for precision therapies using artificial intelligence (AI) on a Polish cohort of colorectal cancer patients.
Methods: We analyzed 71 patients with histopathologically confirmed advanced resectional colorectal adenocarcinoma.
Remote, automatic, digital preanesthetic evaluation - are we there yet?
Anaesthesiol Intensive Ther
August 2024
Recent years have witnessed multiple advancements in the field of information technology in medicine. The need to ensure patient and doctor safety during COVID-19 resulted in improved telemedicine adaptation across various fields, including anaesthesiology. In this review, the authors examine the current state of the elements of preanesthetic evaluation and their remote execution using current and future telemedical facilities and technologies, as well as the potential of future advancements in this field.
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