Publications by authors named "M Borghesani"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are special medicines that help treat certain types of stomach and intestine cancers that have specific gene problems (dMMR/MSI-H).
- These medicines have shown great results, letting doctors skip using some harsh treatments like chemotherapy and surgery for some patients.
- However, scientists are still figuring out how well they work for other types of cancers and are studying how to find the right patients who can benefit the most from these new treatments.
Background: High-grade neuroendocrine neoplasms (NENs) comprise both well-differentiated grade 3 neuroendocrine tumors (G3 NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) nearly always include poorly differentiated NEC as the neuroendocrine component. The efficacy and safety of frontline mFOLFIRINOX chemotherapy has never been investigated in patients with high-grade NENs.
View Article and Find Full Text PDFPromising targetable biomarkers in pancreatic neuroendocrine tumours.
Expert Rev Endocrinol Metab
November 2023
Introduction: In the treatment scenario of PanNETs-targeted therapies are desired but limited, as rarity and heterogeneity on PanNETs pose limitations to their development.
Areas Covered: We performed a literature review searching for promising druggable biomarkers and potential treatments to be implemented in the next future. We focused on treatments which have already reached clinical experimentation, although in early phases.
Non-metastatic neuroendocrine carcinoma of the cervix (NECC) is a rare and aggressive disease. Lacking prospective studies, the optimal multimodal treatment approach has not yet been clearly defined. This study aims to assess the clinical outcomes of patients with non-metastatic NECC treated with surgery and (neo)adjuvant chemotherapy, according to pathologic prognostic factors and multimodal treatments received.
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