Publications by authors named "M Borduas"
Gastric cancer is common globally and has a generally poor prognosis with a low 5-year survival rate. Targeted therapies and immunotherapies have improved the treatment landscape, providing more options for efficacious treatment. The use of these therapies requires predictive biomarker testing to identify patients who can benefit from their use.
View Article and Find Full Text PDFCharacterization of Extracellular Matrix Derived From Porcine Organs Decellularized Using Different Methods.
J Biomed Mater Res B Appl Biomater
November 2024
Article Synopsis
- - Regenerative medicine aims to create tissues and organs, potentially solving organ transplantation challenges by utilizing the extracellular matrix (ECM), which supports cell functions and communication with its unique structure comprised of fibrous proteins and proteoglycans.
- - The study explored four decellularization techniques on porcine organs to produce ECMs, successfully removing cellular components while analyzing their structure through histological methods and protein content differences.
- - Findings showed that the decellularization methods significantly affected the protein composition and orientation within the ECM, highlighting the need for a balance between preserving ECM’s ultrastructure and removing cells for future regenerative therapies.
In Vitro and In Vivo Biocompatibility of Bacterial Cellulose.
J Biomed Mater Res B Appl Biomater
October 2024
Article Synopsis
- * The study assessed the material's cytotoxicity on cell lines and found no harmful effects, while biocompatibility tests in rats showed acute and chronic inflammation due to endotoxins in the membranes.
- * After addressing the endotoxin issue, follow-up experiments indicated that purified bacterial cellulose membranes could be safely used in biomedical applications, leading to minimal inflammation over time.
Introduction: Malignant gastrointestinal neuroectodermal tumor (GNET) is a rare malignancy primarily affecting the gastrointestinal tract. Upon cross-sectional imaging, it can be easily confused with other mesenchymal tumors. This article presents a case of duodenal GNET and reviews the current literature on this rare entity.
View Article and Find Full Text PDFGastrointestinal stromal tumors (GISTs) account for 1% of GI neoplasms in adults, and epidemiological data suggest an even lower occurrence in pregnant women. The majority of GISTs are caused by KIT and PDGFRA mutations. This is not the case in women of childbearing age.
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