The Use of Nutraceutical and Pharmacological Strategies in Murine Models of Autism Spectrum Disorder.

Autism spectrum disorder (ASD) is a common neurodevelopmental condition mainly characterized by both a scarce aptitude for social interactions or communication and engagement in repetitive behaviors. These primary symptoms can manifest with variable severity and are often paired with a heterogeneous plethora of secondary complications, among which include anxiety, ADHD (attention deficit hyperactivity disorder), cognitive impairment, sleep disorders, sensory alterations, and gastrointestinal issues. So far, no treatment for the core symptoms of ASD has yielded satisfactory results in a clinical setting.

External validation of SpineNetV2 on a comprehensive set of radiological features for grading lumbosacral disc pathologies.

Background: In recent years, the integration of Artificial Intelligence (AI) models has revolutionized the diagnosis of Low Back Pain (LBP) and associated disc pathologies. Among these, SpineNetV2 stands out as a state-of-the-art, open-access model for detecting and grading various intervertebral disc pathologies. However, ensuring the reliability and applicability of AI models like SpineNetV2 is paramount.

Which Accessibility for Mountain Natural Environments? The Ski-Ability Project.

The growing desire to live experiences in naturalistic environments that are also opportunities for psycho-physical well-being has meant that the issue of accessibility is now involving environmental contexts that by their nature are often almost inaccessible due to both the morphology of the places and the meteorological-geographical conditions. It is evident that in such contexts the degree of accessibility cannot be fully satised by acting on the environment, it is, therefore, necessary to refer to notions such as reasonable accommodation or equivalent accessibility. In this sense, the degree of accessibility achievable involves more organizational aspects and the provision of special aids, reducing the number and scope of interventions in the physical environment.

Occupational Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-Analysis.

Introduction: Benzene is a recognized carcinogen; however, its association with breast cancer is not well established. Hence, a meta-analysis of cohort and case-control studies was performed to determine the association between occupational benzene exposure and the risk of breast cancer.

Methods: A systematic literature review identified 7573 publications from which 23 cohort and case-control studies were retained and evaluated using meta-analyses (fixed effects model).