Portable System for In-Clinic Differentiation of Skin Cancers from Benign Skin Lesions and Inflammatory Dermatoses.

The exquisite sensitivity of Raman spectroscopy for detecting biomolecular changes in skin cancer has previously been explored; however, this mostly required analysis of excised tissue samples using bulky, immobile laboratory instrumentation. In this study, the technique was translated for clinical use with a portable Raman system and customized fiber optic probe and applied to differentiation of skin cancers from benign lesions and inflammatory dermatoses. The aim was to provide an easy-to-use, easy-to-manage assessment tool for clinicians to use in their daily patient examination routine to perform rapid Raman measurements of skin lesions in vivo.

Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide.

In spite of the progress in treatment strategies, cancer remains a major cause of death worldwide. Therefore, the main challenge should be the early diagnosis of cancer and the design of an optimal therapeutic strategy to increase the patient's life expectancy as well as the continuation of the search for increasingly active and selective molecules for the treatment of different forms of cancer. In the recent decades, research in the field of natural compounds has increasingly shifted towards advanced and molecular level understandings, thus leading to the development of potent anti-cancer agents.

An Overview of Traditional Uses, Phytochemical Compositions and Biological Activities of Edible Fruits of European and Asian Species.

species are widely distributed in central and southern Europe, east Africa, southwest Asia, and America. Several species are known for edible fruits, especially and . These delicious fruits, characterized by their remarkable nutritional and biological values, are widely used in traditional medicine.

Essential Oils and Extracts of Sm. and L.: Comparative Phytochemical Composition and Anti-Proliferative and Antioxidant Activities.

In this work, we conducted a comparative phytochemical, chemotaxonomic, and biological study of essential oils (EOs) and extracts (ethyl acetate and methanol) obtained from the leaves of and . The dominant compounds of EO, analysed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), are α-pinene, sabinene, manoyl oxide, and germacrene D, whereas α-pinene, limonene, (,)-farnesol, β-pinene, and γ-cadinene are the most representative volatiles of EOs. A multivariate analysis of EOs, included a selection of literature data comparing our samples to samples of // from the Mediterranean area, was performed.

An Insight into L. (Lamiaceae) Bioactive Extracts Obtained by Traditional and Green Extraction Procedures.

Even though is one of the most known genera of the Lamiaceae family, some traditionally used species are still now less investigated. To that end, the present study aims to evaluate the chemical profile and the potential bioactivities of extracts and related fractions obtained from the endemic sage L. by applying a traditional extraction method such as Soxhlet apparatus (SHS) and the rapid solid-liquid dynamic extraction (RSLDE) by Naviglio extractor (SHN), considered among the "green techniques" operating at room temperature and with minimum solvent employment and minimum energy.