Publications by authors named "M Bollati"
Spontaneous coronary artery dissection (SCAD) represents a quite rare event but with potentially serious prognostic implications. Meanwhile, SCAD typically presents as an acute coronary syndrome (ACS). Despite the majority of SCAD presentation being characterized by typical ACS signs and symptoms, young age at presentation with an atypical atherosclerotic risk factor profile is responsible for late medical contact and misdiagnosis.
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- Researchers studied 1,729 patients with coronary artery aneurysms (CAAs) to understand their clinical characteristics and predict outcomes, using data from an international registry across 9 countries.
- The majority of patients were male (78.6%) averaging 66 years old, with significant cardiovascular issues such as coronary artery disease (85.8%) and a median of 1 aneurysm per patient, primarily affecting the left anterior descending artery.
- During a median follow-up of about 45 months, 21.9% of patients died, and 37.1% experienced major adverse cardiovascular events; factors like age, diabetes, and kidney disease were linked to worse outcomes.
Protein-protein interactions (PPIs) have been recognized as a promising target for the development of new drugs, as proved by the growing number of PPI modulators reaching clinical trials. In this context, peptides represent a valid alternative to small molecules, owing to their unique ability to mimic the target protein structure and interact with wider surface areas. Among the possible fields of interest, bacterial PPIs represent an attractive target to face the urgent necessity to fight antibiotic resistance.
View Article and Find Full Text PDFPrevention and management of hypertensive crises in children with pheochromocytoma and paraganglioma.
Front Endocrinol (Lausanne)
September 2024
Article Synopsis
- - Hypertensive crises in children are rare and often occur without a prior hypertension diagnosis, potentially linked to underlying issues like pheochromocytoma/paraganglioma (PPGL) that cause catecholamine excess.
- - The type of catecholamine excess varies by tumor type: noradrenergic tumors typically lead to sustained hypertension, while adrenergic tumors may cause paroxysmal hypertension due to a mix of adrenergic receptor stimulation.
- - Treatment for these hypertensive crises mainly involves alpha-blockers, and sometimes beta-blockers for tachyarrhythmias, with the administration route depending on whether it's a hypertensive emergency or urgency.
The cardiometabolic implications of Non-Functioning Adrenal Incidentaloma (NFAI) is still matter of debate. This study takes a novel approach to analyze this association, accounting for the influence of various confounding factors. We present the findings of a retrospective, cross-sectional, and case-control study.
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