Publications by authors named "M Bokarewa"
Hyperinsulinemia connects obesity, and a poor lipid profile, with type 2 diabetes (T2D). Here, we investigated consequences of insulin exposure for T cell function in the canonical autoimmunity of rheumatoid arthritis (RA). We observed that insulin levels correlated with the glycolytic index of CD4+ cells but suppressed transcription of insulin receptor substrates, which was inversely related to insulin sensitivity.
View Article and Find Full Text PDFInhibitory effect of hydroxychloroquine on glucocorticoid-induced osteoporosis in lupus therapy.
Clin Transl Immunology
October 2024
Article Synopsis
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease treated primarily with hydroxychloroquine (HCQ) and glucocorticoids (GCs), but the exact mechanisms of their combined effectiveness remain unclear.
- The study utilized specific models to assess how HCQ enhances the anti-inflammatory effects of GCs by lowering macrophage FcγRI expression and inhibits osteoclast formation, which helps mitigate bone loss.
- Findings suggest that HCQ not only boosts the anti-inflammatory response of GCs but also protects against bone deterioration in lupus patients, providing new insights into treatment strategies.
Background: Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine 4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene expression control during cell differentiation. The role of BvCR in post-transcriptional DNA damage response remains unidentified. Oncoprotein survivin binds chromatin and mediates IFNγ effects in CD4 cells.
View Article and Find Full Text PDFObjective: Activation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint destination of pathogenic leukocytes, the mechanism by which they perpetuate rheumatoid arthritis (RA), and how JAK inhibition mitigates these effects.
Methods: CD14 cells of 136 RA patients were characterized by RNA sequencing and cytokine measurement to identify biological processes and transcriptional regulators specific for CD14 cells, which were summarized in a metabolic signature (MetSig).
Rheumatoid arthritis (RA) is a canonical autoimmune disease that shares numerous risk factors with diabetes mellitus (DM). The production of autoantibodies is a characteristic feature in both diseases. To determine the frequency and specificity of DM-related antibodies (DMab) in RA patients and to study whether DMab associates with new DM cases in RA patients, we measured DMab defined as IgG against glutamic acid decarboxylase (GADA), tyrosine phosphatase (IA2-ab), and zinc transporter (ZnT8-ab) in a cohort of 290 RA patients (215 women and 75 men, median disease duration 11 years).
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