1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration.

The 1,3-dithiolane ring has been recently rehabilitated as a chemical scaffold in drug design. However, for derivatives that are substituted in position 4, the introduction of a chiral center on the heterocycle demands the separation and characterization of the stereoisomers. We report the first chiral resolution and absolute configuration (AC) assignment for (1,4-dithiaspiro[4.

Unraveling the Role of Structural Topology on Chirality Transfer and Chiroptical Properties in Chiral Germanium Iodides.

Chiral hybrid organic-inorganic metal halides are highly promising chiroptoelectronic materials with potential applications in several fields, such as circularly polarized photodetectors, second-order nonlinear optics, and spin-selective devices. However, the ability of manipulating the chiroptical response and the chirality transfer from the organic ligands require one to shed light on structure-property correlations. Herein, we devised and prepared two novel Ge-based chiral hybrid organic-inorganic metal halides showing a different structural topology, namely, a 1D and a 2D arrangement, but composed of the same chemical building blocks: (/-ClMBA)GeI and (/-ClMBA)GeI.

Supramolecular Weaving by Halogen-Bonding in Functionality-Rich Hexasubstituted Aromatic Synthons.

Hexasubstituted benzenes are interesting platforms for the generation of functional materials, whose applications span from supramolecular recognition to organic electronics. Their synthesis is difficult to achieve by controlling multiple substitution steps of all hydrogen atoms on the aromatic benzene skeleton, so, often, cycloaddition reactions from disubsituted alkynes are used. In this work, we report a novel, straightforward route to -symmetrical hexasubstituted aromatic synthons with a diverse and rich pattern of functionalities, and we report about their packing mode in the crystals, in which, unprecedentedly, directional, strong halogen bonding interactions are capable of forming bidimensional supramolecular weaving.

CO Separation by Imide/Imine Organic Cages.

Invited for the cover of this issue are the groups of Valeria Amendola at the University of Pavia, Mariolino Carta at the University of Swansea, and Johannes C. Jansen at the CNR-ITM. The image depicts one of the novel imide/imine organic cages that were employed as fillers in mixed-matrix membranes for the selective separation of CO from N and CH .

CO Separation by Imide/Imine Organic Cages.

Two novel imide/imine-based organic cages have been prepared and studied as materials for the selective separation of CO from N and CH under vacuum swing adsorption conditions. Gas adsorption on the new compounds showed selectivity for CO over N and CH . The cages were also tested as fillers in mixed-matrix membranes for gas separation.