A comparison of febrile responses induced by LPS from E. coli and S. abortus in unrestrained rats placed in a thermal gradient.

The purpose of our study was a comparison of pyrogenic and behavioural effects of Escherichia coli (E.coli) and Salmonella abortus (S.abortus) endotoxins in unrestrained, freely moving Wistar rats, placed in a thermal gradient and having an easy access to ambient temperatures within a range 5-40 degrees C.

A moderate dose of cycloheximide does not prevent the febrile response to endotoxin but interfere with induction of pyrogenic tolerance in rabbit.

The purpose of the present study was to examine the effect of cycloheximide (Cx)--inhibitor of protein synthesis, on the development of pyrogenic tolerance to LPS. It has been observed that Cx at a dose of 1 mg/kg given intravenously 1 h prior to LPS did not prevent fever response, however it modified the induction of pyrogenic tolerance. It was manifested in existence of the second phase of fever after the following administrations of LPS into rabbits pretreated with Cx.

Lack of pyrogenic tolerance transmission between brain and periphery in the rabbit.

Successive injections of lipopolysaccharide (LPS) either intravenously (i.v.) or intracerebroventricularly (i.