Calibrated Ecosystem Models Cannot Predict the Consequences of Conservation Management Decisions.

Ecosystem models are often used to predict the consequences of management interventions in applied ecology and conservation. These models are often high-dimensional and nonlinear, yet limited data are available to calibrate or validate them. Consequently, their utility as decision-support tools is unclear.

Clay hypoplasticity coupled with small-strain approaches for complex cyclic loading.

Constitutive models that are able to accurately predict cyclic soil behaviour are crucial for finite element design of offshore foundation or railway embankments. Basic hypoplastic models introduce the history of loading in state variables such as the stress and void ratio and are therefore incapable of describing small-strain stiffness and cyclic loading. In this work, clay hypoplasticity is extended with a modified intergranular strain proposed by Duque et al.

Spin Spiral State at a Ferromagnetic Gd Vacuum Interface.

Centrosymmetric bulk magnets made of layered Gd intermetallics had been discovered recently to exhibit helical spin spirals with a wavelength of ≈2  nm that transform into skyrmion lattices at certain magnetic fields. Here we report on the observation of a spin spiral state at the Gd(0001) surface. Spin-polarized scanning tunneling microscopy images show striped regions with a periodicity of about 2 nm.

Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity.

Despite Hsp90's well documented promise as a target for developing cancer chemotherapeutics, its inhibitors have struggled to progress through clinical trials. This is, in part, attributed to the cytoprotective compensatory heat shock response (HSR) stimulated through intracellular Hsp90 inhibition. Beyond its intracellular role, secreted extracellular Hsp90 (eHsp90) interacts with numerous pro-oncogenic extracellular clients.