Publications by authors named "M Bocchino"
Quantitative assessment of the extent of radiological alterations in interstitial lung diseases is a promising field of application that goes beyond the limitations of qualitative scoring. Analysis of density histograms, i.e.
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- Predictors of severe COVID-19 cases, specifically the ROX index, were analyzed in a study involving 227 patients hospitalized in Italy during the second pandemic wave, focusing on its ability to predict treatment failures like intubation or death.
- The study found that older age, history of smoking, cardiovascular diseases, and a lower PaO2/FiO2 ratio at admission were linked to a higher likelihood of treatment failure.
- The predictive value of the ROX index improved by the third day of hospitalization, with a critical cut-off value of 8.53 indicating a greater risk of treatment failure in patients on days 1 to 3.
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- Pneumothorax (PNX) is frequent in emergency departments and needs quick diagnosis and treatment; this study examined how well transthoracic ultrasounds (TUSs) identify spontaneous PNX.
- 637 adult patients with chest pain and breathing issues from four Italian hospitals were included, and TUS results were compared to chest CT scans to determine accuracy metrics like sensitivity and specificity.
- TUS accurately identified 89.2% of spontaneous PNX cases but had low specificity (43.8%), indicating it shouldn't be the sole diagnostic tool; TUS results should be corroborated with a chest X-ray or CT scan for proper patient management.
The monocyte-phagocyte system (MPS), including monocytes/macrophages and dendritic cells (DCs), plays a key role in anti-viral immunity. We aimed to analyze the prognostic value of the MPS components on in-hospital mortality in a cohort of 58 patients (M/F; mean age ± SD years) with COVID-19 pneumonia and 22 age- and sex-matched healthy controls. We measured frequencies and absolute numbers of peripheral blood CD169 monocytes, conventional CD1c and CD141 (namely cDC2 and cDC1), and plasmacytoid CD303 DCs by means of multi-parametric flow cytometry.
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