Publications by authors named "M Boattini"
Updates on the Activity, Efficacy and Emerging Mechanisms of Resistance to Cefiderocol.
Curr Issues Mol Biol
December 2024
Article Synopsis
- Novel antimicrobial drugs, like cefiderocol, have been developed to tackle the rise of antimicrobial resistance, specifically against multidrug-resistant (MDR) Gram-negative bacilli (GNB).
- Cefiderocol, a unique siderophore cephalosporin, efficiently penetrates bacterial outer membranes, making it effective against various resistance strategies and offering a broad spectrum of action.
- Despite its effectiveness, recently identified cefiderocol-resistant strains highlight the need for new strategies in clinical practice to maintain its antibacterial efficacy.
Article Synopsis
- The study assesses the effectiveness of new antibiotic combinations against KPC-producing Klebsiella pneumoniae (KPC-Kp) in Italy, focusing on clinical isolates from 2022-2023.
- Both meropenem/vaborbactam and imipenem/relebactam exhibited high susceptibility rates, indicating their potential as effective treatments.
- Resistance to these antibiotics is associated with specific genetic factors, including the presence of KPC gene variants and changes in porin proteins, which affect drug uptake.
Article Synopsis
- The study investigates how KPC variants of Klebsiella pneumoniae develop resistance to new β-lactam/β-lactamase inhibitor combinations (βL/βLICs) among patients treated with these antibiotics.
- Researchers conducted a case series involving four patients with bloodstream infections linked to KPC-Kp, noting that most had underlying health issues and experienced severe complications.
- Resistance mutations were identified in the KPC genes following treatment, emphasizing that the use of novel βL/βLICs can lead to the emergence of resistant strains, particularly against ceftazidime/avibactam.
Article Synopsis
- Respiratory Syncytial Virus (RSV) causes significant respiratory illness in children and older adults, with new preventive strategies emerging.
- A systematic review analyzed 36 studies to explore the relationship between RSV and HIV, focusing on disease incidence and severity, particularly in sub-Saharan Africa.
- Findings indicated no higher incidence of RSV in HIV-infected individuals, but both HIV-positive and HIV-exposed uninfected children faced increased severity and mortality, highlighting the need for targeted prophylactic measures for vulnerable groups.