Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.

RNA polymerase II-dependent transcription requires the assembly of a multi-protein, preinitiation complex on core promoter elements. Transcription factor IID (TFIID) comprising the TATA box-binding protein (TBP) and TBP-associated factors (TAFs) is responsible for promoter recognition in this complex. Subsequent association of TFIIA and TFIIB provides enhanced complex stability.

[Perinatal risk in significant macrosomia. A study based on the databank of the Professional Society of Swiss Gynecologic Clinics 1983-1992].

A comparison of a group of births with severe macrosomia with a group of normal birth weight was made based on the data from the "Arbeitsgemeinschaft schweizerischer Frauenkliniken" (ASF), a work group of Swiss departments of obstetrics and gynaecology. During the period from 1983 to 1992 there were 2911 births of infants weighing more than 4500 g and 222,336 births of infants weighing between 3000 and 4000 g. Overall, the births of the macrosomic infants were more difficult, the rates of secondary Caesarean sections higher and the fetal outcomes poorer.