CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation.

CD47 protects healthy cells from macrophage attack by binding to signal regulatory protein α (SIRPα), while its upregulation in cancer prevents immune clearance. Systemic treatment with CD47 antibodies requires a weakened Fc-mediated effector function or lower CD47-binding affinity to prevent side effects. Our approach combines "the best of both worlds," i.

Prediction of soil available water-holding capacity from visible near-infrared reflectance spectra.

Sustainable land management requires reliable information about soil hydraulic properties. Among these properties, available water-holding capacity (AWC) is a key attribute, as it quantifies the amount of water available for plants that the soil can hold. Since direct measurements of AWC are costly, pedotransfer functions (PTF) are often used to estimate AWC, leveraging statistical relationships with properties that are easier to measure, such as texture, bulk density, and organic carbon content.

Improved hydrological model parametrization for climate change impact assessment under data scarcity - The potential of field monitoring techniques and geostatistics.

According to current climate projections, Mediterranean countries are at high risk for an even pronounced susceptibility to changes in the hydrological budget and extremes. These changes are expected to have severe direct impacts on the management of water resources, agricultural productivity and drinking water supply. Current projections of future hydrological change, based on regional climate model results and subsequent hydrological modeling schemes, are very uncertain and poorly validated.

Simulation of future groundwater recharge using a climate model ensemble and SAR-image based soil parameter distributions - A case study in an intensively-used Mediterranean catchment.

We used observed climate data, an ensemble of four GCM-RCM combinations (global and regional climate models) and the water balance model mGROWA to estimate present and future groundwater recharge for the intensively-used Thau lagoon catchment in southern France. In addition to a highly resolved soil map, soil moisture distributions obtained from SAR-images (Synthetic Aperture Radar) were used to derive the spatial distribution of soil parameters covering the full simulation domain. Doing so helped us to assess the impact of different soil parameter sources on the modelled groundwater recharge levels.

Sensitivity of mGROWA-simulated groundwater recharge to changes in soil and land use parameters in a Mediterranean environment and conclusions in view of ensemble-based climate impact simulations.

This study examines the impact of changing climatic conditions on groundwater recharge in the Riu Mannu catchment in southern Sardinia. Based on an ensemble of four downscaled and bias corrected combinations of Global and Regional Climate Models (GCM-RCMs), the deterministic distributed water balance model mGROWA was used to simulate long-term mean annual groundwater recharge in the catchment for four 30-year periods between 1981 and 2100. The four employed GCM-RCM combinations project an adverse climatic development for the study area: by the period 2071-2100, annual rainfall will decrease considerably, while grass reference evapotranspiration will rise.