The epsilon toxin from Clostridium perfringens stimulates calcium-activated chloride channels, generating extracellular vesicles in Xenopus oocytes.

The epsilon toxin (Etx) from Clostridium perfringens has been identified as a potential trigger of multiple sclerosis, functioning as a pore-forming toxin that selectively targets cells expressing the plasma membrane (PM) myelin and lymphocyte protein (MAL). Previously, we observed that Etx induces the release of intracellular ATP in sensitive cell lines. Here, we aimed to re-examine the mechanism of action of the toxin and investigate the connection between pore formation and ATP release.

Process mining to investigate the relationship between clinical antecedents and injury risk, severity and return to play in professional sports.

Objective: This paper presents an exploratory case study focusing on the applicability and value of process mining in a professional sports healthcare setting. We explore whether process mining can be retrospectively applied to readily available data at a professional sports club (Football Club Barcelona) and whether it can be used to obtain insights related to care flows.

Design: Our study used discovery process mining to detect patterns and trends in athletes' Post-Pre-Participation Medical Evaluation injury route, encompassing five phases for analysis and interpretation.

Effects of flavoring additives on feed intake, growth performance, temperament, and markers of immune function for newly received feedlot cattle.

Ninety Angus × Hereford steers (259.9 ± 36.18 kg body weight [BW]) were used in a 56-d experiment to assess the effects of flavoring additives on feed intake, and stress and immune response of newly received feedlot cattle.

Lightweight Deep Exemplar Colorization via Semantic Attention-Guided Laplacian Pyramid.

Exemplar-based colorization aims to generate plausible colors for a grayscale image with the guidance of a color reference image. The main challenging problem is finding the correct semantic correspondence between the target image and the reference image. However, the colors of the object and background are often confused in the existing methods.

Endoscopic endonasal approach for olfactory groove meningioma resection: Strategies and outcomes in a retrospective case series.

Objective: Though the endoscopic endonasal approach (EEA) is a widely accepted treatment for skull base tumors, the specific use of EEA for olfactory groove meningiomas (OGMs) is debated, with variable outcomes reported in the literature. We review the surgical results of OGM resections for one surgeon including the operative approach, surgical nuances, and outcomes, with a focus on factors relating to patient selection which favor EEA over transcranial approaches.

Methods: We retrospectively reviewed thirteen cases of endoscopic endonasal resection of olfactory groove meningiomas.