Publications by authors named "M Bisschops"

Objective: The Plants for Joints (PFJ) intervention significantly improved pain, stiffness, and physical function, and metabolic outcomes, in people with metabolic syndrome-associated osteoarthritis (MSOA). This secondary analysis investigated its effects on body composition.

Method: In the randomized PFJ study, people with MSOA followed a 16-week intervention based on a whole-food plant-based diet, physical activity, and stress management, or usual care.

View Article and Find Full Text PDF

As a global regulatory mechanism, carbon catabolite repression allows bacteria and eukaryal microbes to preferentially utilize certain substrates from a mixture of carbon sources. The mechanism varies among different species. In Pseudomonas spp.

View Article and Find Full Text PDF
Article Synopsis
  • Unicellular organisms adjust their metabolism to manage growth and maintenance when environmental conditions change, involving a re-allocation of resources under specific cellular limitations.
  • A detailed metabolic model of yeast was developed, incorporating reactions related to protein synthesis and degradation, which helps predict metabolic activity and protein expression based on growth optimization.
  • The model reveals that under limited glucose, mitochondrial restrictions affect growth (e.g., the Crabtree effect), while excess sugars lead to constraints on cytosolic volume, influencing metabolic strategies and protein profiles.
View Article and Find Full Text PDF

Chronic inflammation plays a central role in the pathophysiology of various non-communicable diseases. Dietary interventions can reduce inflammation, in part due to their effect on the gut microbiome. This systematic review aims to determine the effect of dietary interventions, specifically fiber intake, on chronic inflammatory diseases and the microbiome.

View Article and Find Full Text PDF

Microbial production of bulk chemicals and biofuels from carbohydrates competes with low-cost fossil-based production. To limit production costs, high titres, productivities and especially high yields are required. This necessitates metabolic networks involved in product formation to be redox-neutral and conserve metabolic energy to sustain growth and maintenance.

View Article and Find Full Text PDF