Publications by authors named "M Bichler"
Article Synopsis
- Many multiple sclerosis (MS) patients on disease-modifying therapies (DMT) are at higher risk for infections and show weaker responses to vaccinations, making it crucial to check their immunization status before starting DMT.
- A study of 424 MS patients found that while most were vaccinated against common diseases like tetanus and diphtheria, many were under-vaccinated for other illnesses like influenza and pneumonia.
- Younger age, relapsing disease course, and higher education levels were linked to better vaccination rates, while misinformation about vaccines contributed to lower rates, indicating a need for increased educational efforts to improve compliance.
Background: Despite a vaccination rate of 82.0% (n = 123/150), a SARS-CoV-2 (Alpha) outbreak with 64.7% (n = 97/150) confirmed infections occurred in a nursing home in Bavaria, Germany.
View Article and Find Full Text PDFPurpose: Omicron is rapidly spreading as a new SARS-CoV-2 variant of concern (VOC). The question whether this new variant has an impact on SARS-CoV-2 rapid antigen test (RAT) performance is of utmost importance. To obtain an initial estimate regarding differences of RATs in detecting omicron and delta, seven commonly used SARS-CoV-2 RATs from different manufacturers were analysed using cell culture supernatants and clinical specimens.
View Article and Find Full Text PDFArticle Synopsis
- Somatic evolution of cancer genomes leads to different subclones that may affect treatment resistance and offer new therapeutic options in metastatic breast cancer.
- A study analyzed circulating tumor DNA from 46 patients before and after treatment, looking for new mutations that arise during therapy.
- The results showed that while the number of new mutations did not significantly differ between treatment groups overall, the occurrence of new mutations varied significantly among secondary resistant patients depending on whether they received chemotherapy, a combination of chemotherapy and CE maintenance treatment, or solely CE therapy.
- Further research is needed with larger patient groups to confirm these findings.