Tremor Is Highly Responsive to Levodopa in Advanced Parkinson's Disease.

Background: Tremor in Parkinson's disease (PD) is commonly regarded as less responsive to levodopa than bradykinesia and rigidity, with levodopa-resistant PD tremor considered relatively common.

Objective: The aim was to assess the levodopa responsiveness of tremor, bradykinesia, and rigidity in a population with advanced PD.

Methods: We performed a retrospective study of 526 people with PD screened for deep brain stimulation.

Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease.

Neuropsychiatric symptoms are common and disabling in Parkinson's disease (PD), with troublesome anxiety occurring in one-third of patients. Management of anxiety in PD is challenging, hampered by insufficient insight into underlying mechanisms, lack of objective anxiety measurements, and largely ineffective treatments. In this study, we assessed the intracranial neurophysiological correlates of anxiety in PD patients treated with deep brain stimulation (DBS) in the laboratory and at home.

Internal and external modulation of parieto-premotor circuitry in movement disorders.

This scientific commentary refers to 'Increased beta synchronization underlies perception-action hyperbinding in functional movement disorders', by Pastötter . (https://doi.org/10.