Publications by authors named "M Bettini"
Article Synopsis
- Self-reactive T cells in autoimmune diseases can persist and function well without showing typical exhaustion symptoms, despite being exposed to the same antigens over time.
- Research showed that these autoimmune CD4 T cells maintain TCF1 expression even in the absence of infectious signals, which is crucial for their continued function.
- The study also indicated that the Tcf7 gene undergoes specific epigenetic changes during the early stages of autoimmune T cell differentiation, helping to explain why these cells can survive and remain active for longer periods.
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of preterm infants that is associated with life-long morbidities. Inflammatory insults contribute to BPD pathogenesis. Although the proinflammatory cytokine, IL-17a, plays a role in various neonatal inflammatory disorders, its role in BPD pathogenesis is unclear.
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- The increasing rates of allergies and autoimmune diseases in developed countries highlight the need to understand how gut microbiota affects the immune system.
- Changes to the gut microbiota during the crucial early life stage can significantly impact immune development and function.
- This review examines recent findings on the relationship between early-life microbiota and immune health, and explores potential treatments to correct imbalances in gut bacteria during this vulnerable period.
Conventional immunosuppressive functions of CD4Foxp3 regulatory T cells (Tregs) in type 1 diabetes (T1D) pathogenesis have been well described, but whether Tregs have additional non-immunological functions supporting tissue homeostasis in pancreatic islets is unknown. Within the last decade novel tissue repair functions have been ascribed to Tregs. One function is production of the epidermal growth factor receptor (EGFR) ligand, amphiregulin, which promotes tissue repair in response to inflammatory or mechanical tissue injury.
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- The study examined cases of Guillain-Barré syndrome (GBS) following COVID-19 vaccination compared to non-vaccinated GBS cases in Buenos Aires, involving 91 patients treated from March 2020 to March 2022.
- Patients who had been vaccinated showed a higher incidence of cranial nerve involvement and bilateral facial paralysis, but overall clinical severity scores and other neurophysiological characteristics were similar between the two groups.
- The findings suggest a need for further research to clarify any potential link between COVID-19 vaccination and GBS, particularly through ongoing vaccine safety monitoring and epidemiological studies.