Publications by authors named "M Besnier"
The «parcours exercice professionnel»: A response to medical deserts.
J Epidemiol Popul Health
December 2024
To improve human hepatotoxicity prediction, in vitro liver cell models replicating hepatocyte function, drug metabolism, and toxicity are required. Here, we present a protocol for creating 3D primary human hepatocyte (PHH) cell models using the RASTRUM Platform. We describe the process for PHH model generation; procedures for characterizing the PHH model, including viability, albumin production, and CYP450 inducibility; and drug treatment using acetaminophen and troglitazone.
View Article and Find Full Text PDFArticle Synopsis
- * Endothelial colony-forming cells (ECFCs) derived from blood may offer personalized avenues for potential new therapies targeting vascular function in CAD.
- * The study utilizes the Opera Phenix High-Content Screening System to measure mitochondrial superoxide levels in cells, finding that PKT-100, a new drug, can significantly reduce excessive oxidative stress in patient-derived ECFCs, suggesting its potential as a treatment target.
Introduction: Alcohol use disorder (AUD) ranks among the most prevalent psychiatric disorders worldwide. Despite current treatments, more than half of patients relapse within weeks after treatment. In animal models, exposure to environmental enrichment (EE) has been shown to be a promising approach to reduce relapse.
View Article and Find Full Text PDFObjective: To conduct a review of actions proposed by French health care providers to promote the installation of general practitioners.
Method: Descriptive study among health actors in mainland France included website browsing, sending emails and phone calls with standardized questionnaire on the actions carried out to promote installation of general practitioners.
Results: 313 agencies were approached and 192 replied.