The Fallacy of Single Trials: The Need for Multiple Trials in Assessing Running Economy Responses in Advanced Footwear Technology.

In the quest to uncover the underlying mechanisms responsible for the performance-enhancing benefits imparted by advanced footwear technology (AFT), footwear researchers are employing an individual-level approach. In doing so, they hope to unveil individual-specific responses to AFT otherwise masked by a group-level approach. Classifying an individual's response on the basis of running economy (RE) is a logical strategy given that the intended purpose of AFT is to enhance performance; however, caution should be taken when doing so.

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.

Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states.

The psychotomimetic ketamine disrupts the transfer of late sensory information in the corticothalamic network.

In prodromal and early schizophrenia, disorders of attention and perception are associated with structural and chemical brain abnormalities and with dysfunctional corticothalamic networks exhibiting disturbed brain rhythms. The underlying mechanisms are elusive. The non-competitive NMDA receptor antagonist ketamine simulates the symptoms of prodromal and early schizophrenia, including disturbances in ongoing and task & sensory-related broadband beta-/gamma-frequency (17-29 Hz/30-80 Hz) oscillations in corticothalamic networks.