Publications by authors named "M Bernot"
Craniospinal irradiation and/or intraventricular radioimmunotherapy after high-dose chemotherapy and autologous stem cell rescue in patients with CNS retinoblastoma-Safety and outcomes.
Pediatr Blood Cancer
November 2024
Article Synopsis
- The prognosis for patients with central nervous system retinoblastoma (RB) after high-dose chemotherapy and stem cell transplant remains poor, and the effects of radiation therapy used afterward are unclear.
- A study reviewed data from 16 patients with CNS RB who received chemotherapy followed by high-dose stem cell transplant, observing a 75% response rate to initial treatment.
- Patients who received radiation therapy post-transplant had a 62.5% survival rate at 5 years, while those who did not only had a 28.6% survival rate, suggesting that radiation could improve outcomes and warrants further clinical trials.
Prospective multicenter observational real-world study to assess the use, efficacy and safety profile of follitropin delta during IVF/ICSI procedures (DELTA Study).
Eur J Obstet Gynecol Reprod Biol
February 2024
Article Synopsis
- The study evaluated the use and effectiveness of follitropin delta in women undergoing IVF or ICSI, focusing on its safety and dosing patterns in clinical practice after one treatment cycle.
- Conducted in France across 14 centers, 248 women were treated, with 223 being analyzed; the study highlighted that a significant majority of patients followed a standardized dosing algorithm.
- Key findings included an average of 11.3 oocytes retrieved per patient, a clinical pregnancy rate of 35%, and an ongoing pregnancy rate of 29.6%, indicating good efficacy and safety of follitropin delta in IVF/ICSI treatments.
Background: Stage 4a metastatic retinoblastoma (RB) is curable with intensive multimodality therapy including myeloablative chemotherapy with autologous stem cell transplant (HDC-ASCT) and involved field radiation therapy (IFRT). To our knowledge, no data exist on the impact of (a) pre-ASCT disease status, and (b) IFRT to sites of metastatic disease post ASCT on survival.
Procedure: We retrospectively reviewed patients with stage 4a metastatic RB who underwent induction chemotherapy followed by HDC-ASCT, with or without IFRT, to residual tumor sites at Memorial Sloan Kettering Cancer Center (MSKCC) (n = 24).
Pesticide and nitrate transport in an agriculturally influenced stream in Indiana.
Environ Monit Assess
April 2017
Agrochemicals can be transported from agricultural fields into streams where they might have adverse effects on water quality and ecosystems. Three enrichment experiments were conducted in a central Indiana stream to quantify pesticide and nitrogen transport dynamics. In an enrichment experiment, a compound solution is added at a constant rate into a stream to increase compound background concentration.
View Article and Find Full Text PDFWe collaborated with 26 groups from universities across the United States to sample 42 sites for 33 trace organic compounds (TOCs) in water and sediments of lotic ecosystems. Our goals were 1) to further develop a national database of TOC abundance in United States lotic ecosystems that can be a foundation for future research and management, and 2) to identify factors related to compound abundance. Trace organic compounds were found in 93% of water samples and 56% of sediment samples.
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