Publications by authors named "M Beringer"

Background: Electroretinograms (ERG) are usually recorded with non-invasive corneal electrodes, requiring direct contact with the ocular surface. However, corneal electrode application is not tolerated by some individuals. The advent of handheld ERG devices has facilitated the use of skin electrodes for ERG measurements.

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Article Synopsis
  • Previous electroretinogram studies show that people with major depressive disorder (MDD) have reduced retinal contrast gain, affecting their visual perception.
  • The study compares contrast suppression in 21 MDD patients and 23 healthy controls (HC) using various stimuli and finds that MDD patients demonstrate less contrast suppression, especially with high stimulus contrast.
  • These findings suggest that altered dopamine function and changes in retinal processing may contribute to the visual perception issues observed in individuals with MDD.
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The molecular underpinnings and consequences of cycles of whole-genome duplication (WGD) and subsequent gene loss through subgenome fractionation remain largely elusive. Endogenous drivers, such as transposable elements (TEs), have been postulated to shape genome-wide dominance and biased fractionation, leading to a conserved least-fractionated (LF) subgenome and a degenerated most-fractionated (MF) subgenome. In contrast, the role of exogenous factors, such as those induced by environmental stresses, has been overlooked.

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Article Synopsis
  • - The study investigates how depression affects visual processing using the electroretinogram (ERG), focusing on patients with major depressive disorder (MDD) and comparing them to healthy controls (HC).
  • - Results showed that MDD patients had lower contrast sensitivity and reduced pattern ERG (PERG) ratios, indicating alterations in visual processing linked to depression.
  • - The use of a handheld ERG device revealed diminished a-wave amplitudes in MDD patients, highlighting its potential as a practical tool for depression research and suggesting the PERG may serve as an objective marker for the condition.
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In two studies we investigate the role of affective factors and top-down processes underlying production and deliberate control of emotional facial expressions and its neural underpinnings. In Study 1 we examine facial expressions of joy, fear and disgust depending on the emotional content of the visual stimuli (upright faces, inverted faces, emotion inducing pictures without faces). In Study 2 we focus on expressions of joy and disgust depending on gaze direction (with and without eye contact) in a more natural setting with a real person as stimulus.

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