Optimized and wavefront guided corneal refractive surgery using the Carl Zeiss Meditec platform: the WASCA aberrometer, CRS-Master, and MEL80 excimer laser.

The Carl Zeiss Meditec platform for custom ablation incorporates a suite of technology integrating high-resolution wavefront aberrometry (WASCA), corneal surface shape data (TOSCA), energy stabilized excimer laser delivery (MEL80), and surgeon-controlled individualization of the ablation profile (CRS-Master). Together, these components deliver increasingly higher accuracy and sophistication in treatment planning for corneal refractive surgery.

Control of chemical reactions by feedback-optimized phase-shaped femtosecond laser pulses.

Tailored femtosecond laser pulses from a computer-controlled pulse shaper were used to optimize the branching ratios of different organometallic photodissociation reaction channels. The optimization procedure is based on the feedback from reaction product quantities in a learning evolutionary algorithm that iteratively improves the phase of the applied femtosecond laser pulse. In the case of CpFe(CO)2Cl, it is shown that two different bond-cleaving reactions can be selected, resulting in chemically different products.