Publications by authors named "M Beresford"
Article Synopsis
- This study focused on serum IFN-α2 as a potential marker for disease activity and flare prediction in juvenile systemic lupus erythematosus (jSLE).
- Researchers analyzed 222 serum samples from jSLE patients, healthy controls, and juvenile idiopathic arthritis patients to compare IFN-α2 levels across groups and assess its predictive value for disease flares.
- The results indicated that higher IFN-α2 levels were associated with active disease states and could predict flare risk in jSLE patients, suggesting its utility for monitoring and managing the condition.
Background: Awareness of paediatric-specific predictors of damage in Childhood-lupus is needed to inform mitigation measures.
Objectives: To ascertain how clinical and demographic variables correlate with damage accrual and identify predictors of damage.
Methods: Analysis included UK JSLE Cohort Study participants.
Article Synopsis
- Some experts and patients worked together to create a set of important data to help study childhood lupus, a disease that affects children.
- They made two datasets: a Core Dataset with 46 necessary items and an Expanded Dataset with 26 extra items, to help gather more information.
- This new information will help researchers around the world study childhood lupus better by using the same important facts and details.
Objective: Juvenile idiopathic arthritis (JIA)-associated uveitis (JIAU) is a serious JIA comorbidity that can result in vision impairment. This study aimed to identify genetic risk factors within the major histocompatibility complex for JIAU and evaluate their contribution for improving risk classification when combined with clinical risk factors.
Methods: Data on single nucleotide polymorphisms, amino acids, and classical HLA alleles were available for 2,497 patients with JIA without uveitis and 579 patients with JIAU (female 2,060, male 1,015).