Publications by authors named "M Beppu"
Article Synopsis
- Re-occlusion and thrombus formation after mechanical thrombectomy in stroke patients can lead to worse outcomes, but early antiplatelet therapy (APT) may help prevent these issues.
- Current guidelines recommend waiting to use APT after intravenous thrombolysis, which complicates treatment for large vessel occlusion strokes.
- A study of 164 patients in Japan suggests that starting APT early post-thrombolysis is safe, with no significant differences in hemorrhagic events or mortality compared to those who started APT later or not at all.
Article Synopsis
- The study investigated the effect of administering P2Y inhibitors during endovascular treatment (EVT) in patients with anterior circulation thrombosis due to acute ischemic stroke.
- Out of 242 patients analyzed, those who received P2Y inhibitors had a significantly higher rate of carotid artery stenting and better functional outcomes after 90 days compared to those who did not.
- The results showed that patients treated with P2Y inhibitors had an adjusted odds ratio of 6.65 for better outcomes, suggesting a strong positive association with the use of these medications.
Background: Although endovascular therapy (EVT) is effective for large ischemic region strokes, the impact of hyperglycemia remains unclear.
Methods And Results: We analyzed data from the RESCUE-Japan LIMIT (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism-Japan Large Ischemic Core) trial, which randomized stroke patients with Alberta Stroke Program Early Computed Tomography Score of 3 to 5 to EVT versus medical management. Outcomes were compared among patients with normoglycemia (<140 mg/dL), moderate hyperglycemia (≥140, <180 mg/dL), and severe hyperglycemia (≥180 mg/dL) on admission.
The COVID-19 pandemic caused by SARS-CoV-2 has spurred the urgent need for effective antiviral strategies. In this work, we explored the potential of oversulfated kappa-carrageenan (OSKC) in spray-coated facemasks for SARS-CoV-2 inhibition pathway. The sulfated derivative was synthesized with sulfur trioxide pyridine complex in dimethylformamide solution.
View Article and Find Full Text PDFCD44 is a cell receptor glycoprotein overexpressed in circulating tumor cells (CTCs), with levels linked to an increase in metastatic capacity of several tumors. Hyaluronic acid (HA), the natural ligand of CD44, has primarily been investigated for tumor cell interaction in self-assembled polyelectrolyte multilayer films, with little attention given to the complementary polycation. In this study, we screened sixteen different polyelectrolyte multilayer assemblies of HA and chitosan (CHI) to identify key assembly parameters and surface properties that control and govern CTCs adhesion.
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