Publications by authors named "M Benecchi"
Article Synopsis
- - Humoral immunity, which relies on antibodies, struggles against SARS-CoV-2 mutants, while CD8 T cells show more resistance to mutation effects.
- - Analysis of spike variant peptides reveals that mutations can either inhibit or enhance CD8 T cell responses in vaccinated and recovered individuals.
- - The emergence of new T cell function enhancing epitopes may improve antiviral protection and inform the future development of more effective COVID-19 vaccines.
The establishment of safe approaches to attain durable donor-type chimerism and immune tolerance toward donor antigens represents a major challenge in transplantation biology. Haploidentical hematopoietic stem cell transplantation (HSCT) is currently used for cancer therapy either as a T-cell-depleted megadose HSCT following myeloablative conditioning or with T-cell-replete HSCT following nonmyeloablative conditioning (NMAC) and high-dose posttransplant cyclophosphamide (PTCY). The latter approach suffers from a significant rate of chronic graft-versus-host disease (GVHD), despite prolonged immunosuppression.
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- - Two patients developed Acremonium sp. endophthalmitis after cataract surgery performed in the same operating room on the same day.
- - Diagnosis was confirmed through repeated isolation of the fungus from various eye samples and its identification using morphological and molecular techniques.
- - The report highlights the importance of microbiology labs in diagnosing rare infections and calls for increased awareness among surgeons and clinicians regarding this type of endophthalmitis.
Background Context: Fungal spondylodiscitis is often because of Candida albicans or other common Candida species, whereas unusual strains such as Candida sake are often thought to be nonpathogenic.
Purpose: To report the first case of spondylodiscitis caused by C sake and its outcome after antimycotic therapy; as the disease occurred in a patient undergoing hemodialysis (HD), we also discuss the potential conditions related to the uremic state and to HD itself, which may predispose to spondylodiscitis.
Study Design/setting: Case report.
A European multicenter study was performed to evaluate the performance of a new method, based on the transcription-reverse transcription concerted reaction (TRC-2), which enabled one-step amplification and real-time detection of the Mycobacterium tuberculosis 16S rRNA target directly in clinical specimens. A total of 633 respiratory and nonrespiratory specimens were tested, and the results were compared with those from smears and cultures. A total of 129 patients (Paris center) were followed up in order to evaluate the clinical performance of TRC-2.
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