Publications by authors named "M Ben Bacha"

Article Synopsis
  • Tacrolimus shows variability in how it works in different individuals and has a small window between effective and harmful doses, with ongoing debate about the effect of a specific genetic variant (CYP3A5 6986A>G) on this variability.
  • A study on Tunisian kidney transplant recipients examined the effects of this SNP on tacrolimus levels, adverse drug reactions (ADRs), and kidney graft outcomes over five years.
  • Results indicated that patients with the CYP3A5*3 variant had higher tacrolimus concentrations and more ADRs, but this genetic variant did not affect the success of the kidney transplant.
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The ability to accurately predict long-term kidney transplant survival can assist nephrologists in making therapeutic decisions. However, predicting kidney transplantation (KT) outcomes is challenging due to the complexity of the factors involved. Artificial intelligence (AI) has become an increasingly important tool in the prediction of medical outcomes.

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With its robust ability to integrate and learn from large sets of clinical data, artificial intelligence (AI) can now play a role in diagnosis, clinical decision making, and personalized medicine. It is probably the natural progression of traditional statistical techniques. Currently, there are many unmet needs in nephrology and, more particularly, in the kidney transplantation (KT) field.

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Waste generated by healthcare facilities during the COVID-19 pandemic has become a new source of pollution, particularly with the widespread use of single-use personal protective equipment (PPE). Releasing microplastics (MPs) and microfibers (MFs) from discarded PPE becomes an emerging threat to environmental sustainability. MPs/MFs have recently been reported in a variety of aquatic and terrestrial ecosystems, including water, deep-sea sediments, air, and soil.

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Chronic kidney disease (CKD) treated by hemodialysis (HD) is a worldwide major public health problem. Its incidence is getting higher and higher, leading to an alarming social and economic impact. The survival of these patients is significantly low, especially during the first year of treatment.

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