RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.

A G4C2 hexanucleotide repeat expansion in is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). Bidirectional transcription and subsequent repeat-associated non-AUG (RAN) translation of sense and antisense transcripts leads to the formation of five dipeptide repeat (DPR) proteins. These DPRs are toxic in a wide range of cell and animal models.

Emergence of superconductivity by intercalation of alkali metals and alkaline earth metals in Janus transition-metal dichalcogenide heterostructures.

Superconductivity in two-dimensional materials has attracted considerable attention. A new material belonging to the family of Janus transition metal dichalcogenides with out-of-plane structural asymmetry has been recently found to show interesting physical and chemical properties. Using density functional theory and density functional perturbation theory, within the generalized gradient approximation with van der Waals correction, we performed a detailed investigation of the electronic structure, phonon dispersion, Eliashberg spectral function, and electron-phonon coupling of Janus MSSe bilayers (M = Mo or W) and the Janus MoSSe/WSSe heterostructure intercalated with alkali metals (Li, Na, and K) or alkaline earth metals (Mg, Ca, and Sr).

Navigating the phase diagram of quantum many-body systems in phase space.

We demonstrate the unique capabilities of the Wigner function, particularly in its positive and negative parts, for exploring the phase diagram of the spin -(1/2-1/2) and spin-(1/2-1) Ising-Heisenberg chains. We highlight the advantages and limitations of the phase-space approach in comparison with the entanglement concurrence in detecting phase boundaries. We establish that the equal angle slice approximation in the phase space is an effective method for capturing the essential features of the phase diagram but falls short in accurately assessing the negativity of the Wigner function for the homogeneous spin-(1/2-1/2) Ising-Heisenberg chain.

Early screening of sleep disordered breathing in hospitalized stroke patients high-resolution pulse oximetry as prognostic and early intervention tools in patients with acute stroke and sleep apnea (HOPES TRIAL).

Introduction: Sleep Disordered Breathing (SDB) has been shown to increase the risk of stroke and despite recommendations, routine evaluation for SDB in acute stroke is not consistent across institutions. The necessary logistics and expertise required to conduct sleep studies in hospitalized patients remain a significant barrier. This study aims to evaluate the feasibility of high-resolution pulse-oximetry (HRPO) for the screening of SDB in acute stroke.