Publications by authors named "M Bellon"
Article Synopsis
- The cancer incidence rates among adolescents and young adults (AYA) have risen by 30% since 1970, highlighting the need for discussing fertility preservation (FP) before gonadotoxic treatments.
- National guidelines recommend various FP options like oocyte, embryo, and ovarian tissue cryopreservation, with significant progress in the practice of these options since 2013.
- Despite advancements and recommendations, the use of FP services is inconsistent, and factors affecting decision-making—like financial constraints—remain important concerns for patients.
Article Synopsis
- HTLV-1 is linked to diseases like adult T-cell leukemia and HTLV-1-associated myelopathy, prompting researchers to isolate a molecular clone from a patient with HAM/TSP.
- This clone exhibits unique genetic features and viral mRNA patterns, indicating a potential connection to the development of HAM/TSP.
- The study finds that while direct infection of primary T cells with HTLV-1 clones leads to limited cell growth, transmission from dendritic cells enhances long-term proliferation and supports latent infections.
Objective: To assess the safety of fertility-sparing treatments for early-stage ovarian cancer in women younger than 40 years old.
Methods: We performed a retrospective multicenter study including women aged 18-40 years diagnosed with early-stage (FIGO I-II) ovarian cancer in 55 Spanish hospitals, from January 2010 to December 2019. Benign and borderline tumors were excluded, as well as advanced stages (FIGO III-IV).
Given the multitude of challenges Earth is facing, sustainability science is of key importance to our continued existence. Evolution is the fundamental biological process underlying the origin of all biodiversity. This phylogenetic diversity fosters the resilience of ecosystems to environmental change, and provides numerous resources to society, and options for the future.
View Article and Find Full Text PDFUnlabelled: Human T-cell leukemia virus type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL). Mutational analysis has demonstrated that the tumor suppressor, F-box and WD repeat domain containing 7 (FBXW7/FBW7/CDC4), is mutated in primary ATL patients. However, even in the absence of genetic mutations, FBXW7 substrates are stabilized in ATL cells, suggesting additional mechanisms can prevent FBXW7 functions.
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