Publications by authors named "M Bellis"
Background: Evidence indicates that neurodivergent (ND) populations may be more at risk of experiencing adverse childhood experiences (ACEs), compared to neurotypical (NT) populations. However, this evidence has typically not examined a comprehensive set of ACEs and has only included ND individuals on the basis that they have a diagnosis. Very little research has examined the impacts of ACEs on negative adulthood outcomes for ND populations.
View Article and Find Full Text PDFThe benefit of resection of liver metastases depends on primary diseases. Neuroendocrine tumors are associated with favorable prognosis after resection of liver metastases. Gastric cancer has worse tumor biology, and resection of gastric liver metastases should be performed in selected patients.
View Article and Find Full Text PDFArticle Synopsis
- Cancer-associated fibroblasts (CAFs) contribute to the aggressive nature and treatment resistance of intrahepatic Cholangiocarcinoma (iCCA), prompting research into the effects of the Notch1 inhibitor Crenigacestat on this interaction.
- Using both 2D and 3D in vitro models, along with a xenograft setup, the study found that CAFs enhance iCCA cell migration and growth, but Crenigacestat effectively inhibits this cross-talk and reduces tumor growth and fibrosis.
- Overall, targeting the hCAF/iCCA interaction with Crenigacestat presents a promising approach to slowing cancer progression and altering critical cell cycle pathways.
Article Synopsis
- The study aims to develop a Preoperative Recurrence Score (PRS) to predict the risk of early recurrence in patients with perihilar cholangiocarcinoma (PCC) after surgery based on their preoperative imaging.
- Researchers collected data from 215 patients and found significant tumor characteristics (like size and vascular involvement) correlated with recurrence-free survival, successfully validating the PRS model across multiple patient cohorts.
- High PRS scores indicated a higher likelihood of recurrence, suggesting that surgery might not be beneficial for those patients, highlighting the need for careful consideration before proceeding to surgery.