Publications by authors named "M Bellingham"
Article Synopsis
- Chronic exposure to environmental chemicals (ECs) affects human health, leading to non-communicable diseases, and studying these effects in real-world conditions requires animal models that mimic such exposure.
- Research using sheep exposed to biosolids found metabolic changes in offspring, including altered liver gene expression and sex-specific effects on metabolism.
- The study identified significant differences in gene expression and liver function, particularly in male lambs, suggesting that prenatal exposure to low-dose mixtures of ECs disrupts normal metabolic processes and sexual dimorphism in liver function.
Developmental exposure to environmental chemicals (ECs) perturbs establishment and maintenance of the ovarian reserve across the reproductive lifetime, leading to premature follicle depletion and ovarian aging. Considering humans are exposed to a complex mixture of ECs, real-life models assessing their cumulative impact on the ovarian reserve are needed. Biosolids is a source of real-life mixture of ECs.
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- Human reproductive and metabolic health has declined over the last 50 years due to exposure to a mix of environmental chemicals, leading to issues like poor sperm quality, early puberty, and increased obesity.
- The impact of these chemicals is particularly strong during embryo and fetus development, with animal studies showing effects from both single chemicals and mixtures.
- Future research should focus on the effects of complex chemical mixtures across multiple developmental stages to better understand genetic mechanisms and develop strategies for reducing these health risks.
Environmental chemicals (ECs) have been associated with a broad range of disorders and diseases. Daily exposure to various ECs in the environment, or real-life exposure, has raised significant public health concerns. Utilizing the biosolids-treated pasture (BTP) sheep model, this study demonstrates that in-utero exposure to a real-life EC mixture disrupts hypothalamo-pituitary-gonadal (HPG) axis gene expression and reproductive traits in prepubertal (8-week-old, 8w) and adult (11-month-old) male sheep.
View Article and Find Full Text PDFThe Breast Cancer UK-Breast Cancer Prevention Conference addressed risk from environmental pollutants and health behaviour-related breast-cancer risk. Epidemiological studies examining individual chemicals and breast cancer risk have produced inconclusive results including endocrine disrupting chemicals (EDCs) Bisphenol A, per- and polyfluorinated alkyl substances as well as aluminium. However, laboratory studies have shown that multiple EDCs, can work together to exhibit effects, even when combined at levels that alone are ineffective.
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