Publications by authors named "M Behan"

Trifunctional protein deficiency (TFP) is a disorder of fatty acid beta-oxidation associated with metabolic, cardiac, and liver dysfunction in severe forms. We present two siblings diagnosed by newborn screening and confirmed by biochemical testing at birth. Their clinical course was complicated by recurrent rhabdomyolysis, retinopathy, and hypoparathyroidism.

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  • Hermansky-Pudlak syndrome (HPS) is a rare genetic condition linked to severe lung issues, particularly pulmonary fibrosis, with no effective treatments available.
  • The study analyzed endocannabinoids in blood samples from HPS patients and other groups to see if they could serve as early indicators of lung fibrosis, noting an increase in the endocannabinoid anandamide (AEA) in HPS-1 patients.
  • A treatment involving zevaquenabant was found to reduce elevated AEA levels and slow down lung fibrosis progression in mouse models, suggesting that AEA could be a potential blood biomarker for monitoring PF in HPS.
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Background: Primary percutaneous coronary intervention (pPCI) has improved clinical outcomes in patients with ST-segment-elevation myocardial infarction. However, as many as 50% of patients still have suboptimal myocardial reperfusion and experience extensive myocardial necrosis. The PiCSO-AMI-I trial (Pressure-Controlled Intermittent Coronary Sinus Occlusion-Acute Myocardial Infarction-I) evaluated whether PiCSO therapy can further reduce myocardial infarct size (IS) in patients undergoing pPCI.

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  • The COVID-19 pandemic led to significant treatment delays for patients needing transcatheter aortic valve replacement (TAVR), with a marked decrease in procedure volumes during the first two waves of the pandemic.
  • The study analyzed TAVR case data from 130 centers in 61 countries, finding a 15% drop in cases during the first wave and 7% in the second, particularly affecting regions like Africa, Central-South America, and Asia.
  • Factors such as hospital type (private vs public), urban vs rural location, low procedure volumes, a country's socioeconomic status, and stringent public health measures contributed to these reductions, highlighting the need for improved public health policies for future health crises.
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  • This study investigates inconsistencies between various measures of blood sugar, particularly HbA1c, fructosamine, and continuous glucose monitoring (CGM) in managing diabetes in primary care.
  • Over a period of about 90 days, they assessed these measures in adults with prediabetes or type 2 diabetes, finding a significant mismatch in results, particularly with HbA1c compared to fructosamine and CGM.
  • The findings suggest that relying solely on HbA1c can lead to misleading diabetes management decisions, emphasizing the need to consider multiple measures for a more accurate clinical assessment.
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