Publications by authors named "M Beckwith"
Article Synopsis
- Clinical intuition plays a crucial role in differential diagnosis, but current algorithms for rare genetic diseases overlook this aspect and assume equal chances for all possible Mendelian diseases.
- The new ClintLR algorithm enhances the existing LIRICAL algorithm by adjusting the pretest probabilities of related diseases based on clinical intuition.
- Simulation results indicate that ClintLR significantly improves the ranking of accurate diagnoses in genetic sequencing, making it a valuable tool available for free online.
A 36-yr-old female intact hybrid orangutan ( sp.) presented with evidence of chronic bacterial cystitis with no response to treatment with multiple systemic antibiotics. Abnormalities were identified within the reproductive tract on CT scan, and hysteroscopy was pursued based on the recommendation of an obstetrician-gynecologist.
View Article and Find Full Text PDFTo navigate through diverse tissues, migrating cells must balance persistent self-propelled motion with adaptive behaviors to circumvent obstacles. We identify a curvature-sensing mechanism underlying obstacle evasion in immune-like cells. Specifically, we propose that actin polymerization at the advancing edge of migrating cells is inhibited by the curvature-sensitive BAR domain protein Snx33 in regions with inward plasma membrane curvature.
View Article and Find Full Text PDFArticle Synopsis
- * Phenopacket-tools is an open-source Java library that makes it easier to build, convert, and validate these phenopackets by providing user-friendly tools and predefined components.
- * The library supports developers in standardizing the collection and sharing of clinical data to enhance genomic diagnostics, research, and precision medicine, with detailed documentation and tutorial resources available online.
Summary Of Background Data: Establishing routine intravenous (IV) access prior to interventional pain procedures performed without sedation is controversial. Anecdotally, practices very in terms of their use of routine IV access.
Objectives: To determine the frequency with which routine IV access is obtained for various common interventional pain procedures among interventional pain providers.