Publications by authors named "M Bebarova"
Article Synopsis
- - Aminophylline, a medication often used for severe asthma, can cause arrhythmias, but the exact reasons are not clear
- - In research, aminophylline significantly inhibited the inward rectifier potassium current in both healthy pig heart cells and failing human heart cells at different concentrations
- - The study found that aminophylline prolonged action potential duration in porcine heart cells, indicating its potential role in causing arrhythmias, suggesting further exploration of its effects on other ionic currents is necessary
The combination of aminophylline and salbutamol is frequently used in clinical practice in the treatment of obstructive lung diseases. While the side effects (including arrhythmias) of the individual bronchodilator drugs were well described previously, the side effects of combined treatment are almost unknown. We aimed to study the arrhythmogenic potential of combined aminophylline and salbutamol treatment in vitro.
View Article and Find Full Text PDFHuman induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) isolated from two related patients diagnosed with either idiopathic ventricular fibrillation or catecholaminergic polymorphic ventricular tachycardia, carrying an unknown variant in the RYR2 gene, c.14201A>G (p.Y4734C) and one healthy related individual.
View Article and Find Full Text PDFThe sarcolemmal Ca efflux pathways, Na-Ca-exchanger (NCX) and Ca-ATPase (PMCA), play a crucial role in the regulation of intracellular Ca load and Ca transient in cardiomyocytes. The distribution of these pathways between the t-tubular and surface membrane of ventricular cardiomyocytes varies between species and is not clear in human. Moreover, several studies suggest that this distribution changes during the development and heart diseases.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers analyzed data from 514 ACA patients, identifying 46 who met specific criteria for an advanced diagnostic work-up, which included various imaging and testing methods.
- * Results showed that 37% of patients had a specific disease discovered, while true idiopathic VF was confirmed in only 15.2%, suggesting that even partial diagnostic efforts can lead to meaningful findings for targeted treatment.